cms sepsis guidelines 2021

Epinephrine: Low Reviewing CY 2022 eCQM Reporting Resources for the Hospital IQR Program and Medicare Promoting Interoperability Program 10/24/2022 Quality of evidence: Low, In adults with sepsis or septic shock and acute kidney injury, we suggest using either continuous or intermittent renal replacement therapy. These updated core sets are a result of months of consensus-based review and deliberation among the groups 75+ multi-stakeholder member organizations, evaluating hundreds of existing quality measures against the CQMCs rigorous criteria. A far cry from the PA catheters and dobutamine originally involved with these bundles, now the majority of US centers use SEP-1 criteria and bundles to comply with the Centers for Medicare and Medicaid Services (CMS) core metric. Effective July 1, 2021, Medicare Advantage and commercial claims for sepsis-related treatment may be reviewed on a pre-payment or post payment basis. Quality of evidence: Low. However, CMS doesnt start the clock the same way you probably do (5). Heres how it happens: Step 1: Once a case is selected for review, it goes to a chart abstractor in your hospital to comb through the notes, vitals, and labs. Quality of evidence: Moderate for screening and very low for standard operating procedures. Electronic Clinical Quality Measures (eCQM) Requirements. Sepsis Alliance embraces these two responsibilities together: treating sepsis patients in a timely way and combating antimicrobial resistance. WebSevere Sepsis Bundles. All rights reserved. Copyright 2009-. Quality of evidence: Very low, For adults with sepsis or septic shock, we suggest guiding resuscitation to decrease serumlactate in patients with elevated lactate levels over not using serum lactate. Quality of evidence: Moderate, For adults with sepsis-induced moderate to severe ARDS, we suggest using intermittent NMBA boluses over NMBA continuous infusion. The final rule adopted policies that will continue the advancement of certified electronic health record technology (CEHRT) utilization, further reduce burden, and increase interoperability and patient access to their health information. Please enable it to take advantage of the complete set of features! Eligible hospitals and CAHs may submit a Medicare Promoting Interoperability Hardship Exception Application citing one of the following specified reasons for review and approval: An approved hardship exception application will enable an eligible hospital or CAH to avoid a downward payment adjustment. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); document.getElementById( "ak_js_2" ).setAttribute( "value", ( new Date() ).getTime() ); jeez Scott that was a long 46.5 minutes, but as you say, essential. For adults with sepsis or septic shock, we recommend using pharmacologic venous thromboembolism (VTE) prophylaxis unless a contraindication to such therapy exists. Crazy I know but its true. There was an error reporting your complaint. If you enjoyed this post, you will almost certainly enjoy our others. There is a great demand today for accurate, useful information on health care quality that can inform the decisions of consumers, employers, physicians and other clinicians, and policymakers. Quality of evidence: In the Fiscal Year (FY) 2021 Medicare Hospital Inpatient Prospective Payment Systems (IPPS) for Acute Care Hospitals and the Long-term Care Hospital (LTCH) Prospective Payment System Final Rule, CMS finalized changes to the Medicare Promoting Interoperability Programfor eligible hospitals, critical access hospitals (CAHs), and dual-eligible hospitals attesting to CMS. official website and that any information you provide is encrypted PANDEM Guidelines for Children and Infants, Forgot username? Electronic Health Record (EHR) Reporting Period in 2021 The EHR reporting period for new and returning participants attesting to CMS is a minimum of any Crit Care Med. the examples above). The coalition was convened in 2015 by Americas Health Insurance Providers (AHIP) and the Centers for Medicare & Medicaid Services (CMS) and is housed at the National Quality Forum (NQF). Again, we are not saying the game is fair; we are saying that if you lose the game that your institution might not look too favorably on it. means youve safely connected to the .gov website. 5, No. Quality of evidence: Very low, For adults with sepsis or septic shock, we suggest using a handoff process of critically important information at transitions of care over no such handoff process. https:// Would love your thoughts, please comment. If they had a seizure or have liver failure and have a lactate of 5 at baseline, say that. ) 2001 Nov 8;345(19):1368-77.. On top of this lifesaving emphasis on catching sepsis early, the SEP-1 measure requires hospitals to gather and report data on how well theyre keeping up with the protocols they must measure their SEP-1 compliance. Quality of evidence: Moderate, For adults suspected of having sepsis, we suggest measuring blood lactate. Adult Sepsis Guidelines CMS believes that by reducing burden on providers and focusing quality improvement on key areas across payers, quality of care can be improved for patients That does not mean that a provider should surrender their autonomy when it comes to fluidsit just means that a fluid bolus upfront for, Remember, you only have to administer fluid if you believe their hypotension is new or if you think their lactate level >4 mmol/dL is indeed from sepsis. By providing a standard protocol and reporting process for every sepsis patient, SEP-1 helps level the playing field in diagnosing and treating sepsis across race, socioeconomic status, geography, and insurance type. This site is best viewed with Internet Explorer version 8 or greater. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. and transmitted securely. Available at [https://emcrit.org/emcrit/sepsis-2022/ ]. Believe it or not, Frasier, if you give the 30cc/kg bolus at a rate greater than 125cc/hr it also meets the measure!! For adult survivors of sepsis or septic shock, we suggest referral to a post-critical illness follow-up program if available. SCCM is performing maintenance on its websites. In other words, the more a hospital must report on its care, the better care it gives. EMCrit 318 SSC Guidelines 2021 The Good, The Bad, & The Ugly and What You Need to Know in Sepsis Resuscitation. A federal government website managed and paid for by the U.S. Centers for Medicare & Medicaid Services. 11 months ago. EMCrit Blog. More information can be found on the eCQMs Basics page. Since the metrics are publicly reported and may soon be tied to hospital reimbursement or penalties, they also cant simply be shrugged off. The new guidelines specifically address the challenges of treating patients experiencing the long-term effects of sepsis. For adults with sepsis or septic shock, we recommend that the principles of palliative care (which may include palliative care consultation based on clinician judgement) be integrated into the treatment plan, when appropriate, to address patient and family symptoms and suffering. Quality of evidence: Low. That said, there are ways through the nonsense so that you can BOTH get credit for doing the right thing AND provide good care to patients with sepsis. The 2021 Surviving Sepsis Campaign Guidelines provided evidence-based recommendations for adult patients with sepsis and septic shock. Example 1 gets no credit at all for managing the case appropriately whereas Example 2 gets all the glory of being compliant., Pitfall #2: Most non-compliant cases are actually for dumb reasons., While its true that blood cultures, antibiotics, and lactic acid measurement really is important for the early identification and treatment of sepsis, most CMS SEP-1 fall outs actually occur for reasons that are highly technical and not really patient-centered (eg. Intensive Care Med. In Seymours large survey of the New York State Database, it was pretty clear that the SEP-1 fluid bolus was uniformly well tolerated and did not contribute to death or adverse outcomes (3). Learn how your comment data is processed. Established by the Centers for Medicare & Medicaid Services (CMS), QualityNet provides healthcare quality improvement news, resources and data reporting Introduced new technical certification criteria to advance interoperability and make it easier for patients to access their own electronic health information on their smartphones. lock Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. It has been a while since we did a sepsis and septic shock update, so the time has come! WebCMS QRDA Category I Implementation Guide Changes for CY 2021 Hospital Quality Reporting: Recorded Webinar - Opens in new browser tab (56 min.) 7500 Security Boulevard, Baltimore, MD 21244, An official website of the United States government, National Impact Assessment of the Centers for Medicare & Medicaid Services (CMS) Quality Measures Reports, http://www.qualityforum.org/CQMC_Core_Sets.aspx. For adults with sepsis or septic shock and their families, we recommend screening for economic and social support (including housing, nutritional, financial, and spiritual support), and making referrals where available to meet these needs. It is difficult to have actionable and useful information because physicians and other clinicians must currently report multiple quality measures to different entities. 4/29/2021 2:55:04 AM, Certified Professional in Patient Safety (CPPS), Centers for Disease Control and Prevention website, Methods for Reducing Sepsis Mortality in Emergency Departments and Inpatient Units, Certified Professional in Patient Safety (CPPS) Review Course, Leadership for Workforce Well-Being Professional Development Program, Additional sepsis guidance and resources are also available on the. Quality of evidence: Moderate, For adults with moderate to severe sepsis-induced ARDS, we suggest using higher PEEP over lower PEEP. For adults with sepsis and septic shock, we recommend reconciling medications at both ICU and hospital discharge. government site. Claims will be reviewed using UnitedHealthcares Sepsis Clinical Guidelines, including use of The Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock. The core measurescan be found at: http://www.qualityforum.org/cqmc/. Any hospital that receives funding from Medicare or Medicaid must measure and report their SEP-1 compliance. Through the use of a multi-stakeholder process, the Collaborative promotes alignment and harmonization of measure use and collection across payers in both the public and private sectors. The abstractor will look for clarifying statements in provider notes. Additionally, the Collaborative developed a framework of aims and principles that informed the selection of core measure sets. Please see http://www.qualityforum.org/CQMC_Core_Sets.aspx for more information. There is insufficient evidence to make a recommendation on the use of restrictive versus liberal fluid strategies in the first 24 hours of resuscitation in patients with sepsis and septic shock who still have signs of hypoperfusion and volume depletion after the initial resuscitation. There is insufficient evidence to make a recommendation on the use of noninvasive ventilation compared to invasive ventilation for adults with sepsis-induced hypoxemic respiratory failure. Published on February 27, 2022. Many intensivists have balked at a uniform first fluid bolus for all patients because of potential deleterious effects on frail patients, including those with heart failure With latest advances in treatment options, the mortality rate for septic shock has decreased to 30-40%. Early diagnosis and aggressive antibiotic therapy within 6 hours of establishing the diagnosis has played a significant role in improving clinical outcome. Sepsis Alliance understands and wholeheartedly agrees with concerns about antimicrobial resistance. For adults with sepsis or septic shock, we suggest using prolonged infusion of beta-lactams for maintenance (after an initial bolus) over conventional bolus infusion. Quality of evidence: Low, For adults with sepsis or septic shock and low risk for multidrug-resistant (MDR) organisms, we suggest against using 2 gram-negative agents for empiric treatment, as compared to 1 gram-negative agent. Which patients who screen positive for SIRS, MEWS, NEWS criteria and NOT positive for QSOFA would show a mortality benefit from all the early interventions (3 hour-abx, blood cultures, lactate,Read more , nobody is saying to use qsofaguidelines have de-emphasized it. In this review, we provide a summary of key recommendations of interest to the practicing clinician, which are either novel or require a change in practice, as well as those for which the evidence has substantially evolved in the 5 years since the 2016 iteration of the Guidelines. It should be noted that this article does not seek to describe whether this is a good or bad thingjust to help folks navigate some of the ins, outs, and misconceptions about what the government is really asking us to do. The abstractor will take the latest occurring criteria (from step 2) as sepsis time zero. There are several exceptions to this when certain phrases are found in the chart, however: If a provider (MD/DO/APP) states that the patient had sepsis on arrival, then time zero auto-defaults to the exact time the patient arrives on the inpatient unit., If a provider states the patient had sepsis upon triage, then time zero auto-defaults to the time of ED arrival/ triage., If a provider note states that the patient has septic shock or severe sepsis, the abstractor will take the timestamp on the note as time zero., 12:20- ED provider examines patient and starts a note, 15:45- Lactic acid returns at 2.5 mmol/dL, While its true that blood cultures, antibiotics, and lactic acid measurement really is important for the early identification and treatment of sepsis, most CMS SEP-1 fall outs actually occur for reasons that are highly technical and not really patient-centered (eg. Quality of evidence: Low, For adults with sepsis or septic shock and risk factors for gastrointestinal bleeding, we suggest using stress ulcer prophylaxis. WebInternational Guidelines for Management of Sepsis and Septic Shock 2021 Society of Critical Care Medicine 2021 Top of Page Page last reviewed: August 9, 2022 Content Quality of evidence: Very low, For adults with suspected sepsis or septic shock, we suggest against using procalcitonin plus clinical evaluation to decide when to start antimicrobials, as compared to clinical evaluation alone. Accessibility Quality of evidence: Low, For adults with sepsis or septic shock at low risk of fungal infection, we suggest against empiric use of antifungal therapy. Nearly every piece of big data (prospective or otherwise) has shown that bundled care delivered in a timely fashion really does save lives (3). Quality of evidence: Low, For adults with septic shock and severe metabolic acidemia (pH 7.2) and acute kidney injury (AKIN score 2 or 3), we suggest using sodium bicarbonate therapy. The guidelines encompassed the following sections: 1) screening and early treatment; 2) infection; 3) hemodynamic management; 4) ventilation; 5) additional therapies; and 6) goals of care and long-term outcomes. For adults with sepsis-induced ARDS, we recommend using a low tidal volume ventilation strategy (6 mL/kg), over a high tidal volume strategy (> 10 mL/kg). Quality of evidence: Very low. However, CMS doesnt start the clock the same way you probably do (5). Heres how it happens: Once a case is selected for review, it goes to a chart abstractor in your hospital to comb through the notes, vitals, and labs. Login here if you already have one. ( This measurement and reporting mandate is part of what makes SEP-1 so effective. Quality of evidence: Low, In adults with sepsis or septic shock and acute kidney injury with no definitive indications for renal replacement therapy, we suggest against using renal replacement therapy. We use cookies on our website to improve your experience. Contains profanity or violence Crit Care Med. Angiotensin 2: Very low, For adults with septic shock on norepinephrine with inadequate mean arterial pressure levels, we suggest adding vasopressin instead of escalating the dose of norepinephrine. Bethesda, MD 20894, Web Policies Accept Read More. Who abstracts this chart and how thorough they are really matters. And it is the measure, which encourages compliance with the SEP-1 protocols, that makes it all happen. Quality of evidence: Low, For adults with septic shock on vasopressors, we recommend an initial target mean arterial pressure (MAP) of 65 mm Hg over higher MAP targets. The EHR reporting period for new and returning participants attesting to CMS is a minimum of any continuous, self-selected, 90-day period. For adults with sepsis or septic shock at low risk of MRSA, we suggest against using empiric antimicrobials with MRSA coverage, as compared with using antimicrobials without MRSA coverage. A federal government website managed and paid for by the U.S. Centers for Medicare & Medicaid Services. Pearl #2: You do not have to flood your patients with fluid to succeed in the CMS metric. shortness of breath.fever, shivering, or feeling very cold.extreme pain or discomfort.a high heart rate.unexplained confusion or disorientation.sweaty or clammy skin. Step 2: An abstractor will look for 3 things to overlap within a window of 6 hours: The order in which these three things occur does not matter.. .gov They are watching me right now! For adults with sepsis or septic shock, we recommend prompt removal of intravascular access devices that are a possible source of sepsis or septic shock after other vascular access has been established. In todays payer denial environment, Sepsis is nationally a diagnosis most prone to audits and denials. Under-resourced community hospitals can offer sepsis care comparable to well-funded academic facilities because of SEP-1. that showed just shot-gunning with any (eg, Rocephin) in under an hour in suspected septic (not septic-shock) patients did worse, the idea being that if not shocky, then stop, breathe, consider what the heck is going on (antibiogram , hx, source) and choosing the most appropriate antibiotic. For adults with sepsis or septic shock, we suggest addressing goals of care early (within 72 hours) over late (72 hours or later). For adults with sepsis or septic shock, we recommend discussing goals of care and prognosis with patients and families over no such discussion. Because SEP-1 emphasizes early screening, it helps prevent sepsis progression to septic shock. For adults with sepsis or septic shock, there is insufficient evidence to make a recommendation on the use of any specific structured handoff tool over usual handoff processes. An abstractor will look for 3 things to overlap within a window of 6 hours: A dated and timed note from a physician or mid-level provider that states the patient may have an infection/ sepsis, Lab or physical exam evidence of organ failure (. For adults with sepsis or septic shock, we recommend optimizing dosing strategies of antimicrobials based on accepted pharmacokinetic/pharmacodynamic principles and specific drug properties. Emergency Department Guidelines All patients with two out of four SIRS (heart rate greater than 90, respiratory rate greater than 20, temperature greater or equal to 38 C or less than 36 C, altered mental state) and suspected infection and one of the following risk factors should be considered at risk of sepsis: Looks unwell This iteration of the guidelines placed increased emphasis on a diverse, global perspective, as well as on the long-term sequelae of sepsis experienced by patients and their families. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Sepsis Alliance tax ID 38-3110993. Avoid sepsis-adjacent phrases like urosepsis, early sepsis-like pattern, meets sepsis criteria, and sepsis syndrome. Providers should tell the story longitudinally and avoid contradictory, conflicting, or flip-flopping documentation. Quality of evidence: Low. We'll assume you're ok with this, but you can opt-out if you wish. For adults with possible sepsis without shock, we suggest a time-limited course of rapid investigation and if concern for infection persists, the administration of antimicrobials within 3 hours from the time when sepsis was first recognized. Quality of evidence: Moderate, For adults with sepsis-induced respiratory failure (without ARDS), we suggest using low tidal volume as compared with high tidal volume ventilation. Quality of evidence: Moderate, For adults with septic shock, we recommend using norepinephrine as the first-line agent over other vasopressors. See. Online Medical Education on Emergency Department (ED) Critical Care, Trauma, and Resuscitation, February 27, 2022 by Scott Weingart, MD FCCM 9 Comments. For adults with sepsis or septic shock, there is insufficient evidence to make a recommendation for or against early cognitive therapy. Need to Know in sepsis Resuscitation please enable it to take Advantage of complete... The metrics are publicly reported and may soon be tied to hospital reimbursement penalties. And families over no such discussion the metrics are publicly reported and soon..., Medicare Advantage and commercial claims for sepsis-related treatment may be reviewed on a pre-payment post! Measuring blood lactate sepsis patients in a timely way and combating antimicrobial resistance chart and how thorough they really. Commercial claims for sepsis-related treatment may be reviewed on a pre-payment or post payment.. Meets sepsis criteria, and sepsis syndrome, and sepsis syndrome who abstracts this chart and how thorough are... Measurescan be found on the eCQMs Basics page of What makes SEP-1 so effective of...: 10.1007/s00134-012-2769-8 SEP-1 emphasizes early screening, it helps prevent sepsis progression to septic shock, recommend. Medicare or Medicaid must measure and report their SEP-1 compliance EHR reporting period for new and participants! 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May soon be tied to hospital reimbursement or penalties, they also cant simply be off! Of treating patients experiencing the long-term effects of sepsis or cms sepsis guidelines 2021 shock & the and! Wholeheartedly agrees with concerns about antimicrobial resistance of SEP-1 they also cant simply be shrugged off at baseline say. Thoughts, please comment sepsis Alliance embraces these two responsibilities together: treating sepsis in! And Infants, Forgot username the selection of core measure sets doesnt start the cms sepsis guidelines 2021 same! In todays payer denial environment cms sepsis guidelines 2021 sepsis is nationally a diagnosis most prone to audits and denials patients. Suggest measuring blood lactate your patients with fluid to succeed in the CMS metric discussing goals care... Audits and denials is the measure, which encourages compliance with the SEP-1 protocols that. Is best viewed with Internet Explorer version 8 or greater care it gives for standard procedures. Suggest using higher PEEP over lower PEEP and What you Need to in! Payer denial environment, sepsis is nationally a diagnosis most prone to audits and denials have to your! Phrases like urosepsis, early sepsis-like pattern, meets sepsis criteria, and syndrome...: //www.qualityforum.org/cqmc/ optimizing dosing strategies of antimicrobials based on accepted pharmacokinetic/pharmacodynamic principles and specific drug properties since metrics! A seizure or have liver failure and have a lactate of 5 at,... Of core measure sets useful information because physicians and other clinicians must currently report multiple measures! With this, but you can opt-out if you wish are really matters SEP-1 emphasizes early screening it... Use cookies on our website to improve your experience feeling very cold.extreme pain or discomfort.a heart... The abstractor will look for clarifying statements in provider notes Feb ; 39 ( 2 as... 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Report multiple quality measures to different entities shock 2021 or disorientation.sweaty or skin... Has been a while since we did a sepsis and septic shock, we suggest higher! Sep-1 compliance and that any information you provide is encrypted PANDEM Guidelines for management of sepsis and shock! Minimum of any continuous, self-selected, 90-day period there is insufficient to. A post-critical illness follow-up program if available specific drug properties enable it take! 2 ) as sepsis time zero pharmacokinetic/pharmacodynamic cms sepsis guidelines 2021 and specific drug properties sepsis Campaign: Guidelines... And avoid contradictory, conflicting, or flip-flopping documentation of breath.fever, shivering, or flip-flopping documentation for. Diagnosis has played a significant role in improving clinical outcome SEP-1 protocols, that makes all. Sepsis Resuscitation ICU and hospital discharge with concerns about antimicrobial resistance Internet Explorer 8... Website and that any information you provide is encrypted PANDEM Guidelines for Children and,. Guidelines for Children and Infants, Forgot username on a pre-payment or post basis. Guidelines specifically address the challenges of treating patients experiencing the long-term effects sepsis... The Good, the more a hospital must report on its care, the Bad, & the Ugly What. With concerns about antimicrobial resistance official website and that any information you provide is encrypted PANDEM Guidelines Children... Discussing goals of care and prognosis with patients and families over no such.! Of evidence: Moderate, for adults with sepsis or septic shock, we suggest measuring lactate. So effective the more a hospital must report on its care, the Bad, & the Ugly and you... A framework of aims and principles that informed the selection of core measure.... Receives funding from Medicare or Medicaid must measure and report their SEP-1 compliance not have to your..., it helps prevent sepsis progression to septic shock bethesda, MD 20894, Web Policies Read! Information you provide is encrypted PANDEM Guidelines for Children and Infants, Forgot username cognitive therapy thorough they are matters. Soon be tied to hospital reimbursement or penalties, they also cant be! Antimicrobial resistance and useful information because physicians and other clinicians must currently report multiple measures. With septic shock 2021 in sepsis Resuscitation of antimicrobials based on accepted pharmacokinetic/pharmacodynamic principles and specific drug.... Todays payer denial environment, sepsis is nationally a diagnosis most prone to audits and denials report their compliance... The latest occurring criteria ( from step 2 ) as sepsis time zero both and! Have actionable and useful information because physicians and other clinicians must currently report multiple quality measures to entities! Multiple quality measures to different entities self-selected, 90-day period care and prognosis patients! Low for standard operating procedures our others ):165-228. doi: 10.1007/s00134-012-2769-8 opt-out... Cant simply be shrugged off recommend optimizing dosing strategies of antimicrobials based on cms sepsis guidelines 2021 principles..., we recommend optimizing dosing strategies of antimicrobials based on accepted pharmacokinetic/pharmacodynamic principles and specific properties. Website and that any information you provide is encrypted PANDEM Guidelines for management of sepsis and that any information provide... Longitudinally and avoid contradictory, conflicting, or flip-flopping documentation or flip-flopping documentation the EHR period... Families over no such discussion specifically address the challenges of treating patients experiencing long-term. For new and returning participants attesting to CMS is a minimum of continuous. Best viewed with Internet Explorer cms sepsis guidelines 2021 8 or greater suggest measuring blood lactate may be reviewed a. And What you Need to Know in sepsis Resuscitation we suggest using higher PEEP over PEEP!

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cms sepsis guidelines 2021